Injection of colchicine in intra-hippocampal cortical area 1 enhances novelty seeking behavior
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چکیده
منابع مشابه
Toxic Effect of Colchicine on Hippocampal Cortical Area
Background and Objectives: Study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. In this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (CA1) was examined by the studying the hippocampal tissue. Materials and Methods: Injections of colchicine (1-75 μg/rat, intra- hippocampal CA1) were performed in cannulated male Wistar rat...
متن کاملtoxic effect of colchicine on hippocampal cortical area
background and objectives: study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. in this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (ca1) was examined by the studying the hippocampal tissue. materials and methods: injections of colchicine (1-75 μg/rat, intra- hippocampal ca1) were performed in cannulated male wistar rat...
متن کاملتاثیر گالانتامین بر برگشت فعالیت حرکتی تشدید یافته در اثر میکرواینجکشن کلشی سین در هیپوکامپ موش ویستار
Background and Objective: Deleterious effect of neurotoxins on the brains of animals is an attractive research topic. In this research, the effect of microinjection of colchicine into the hippocampal CA1 was shown by examining the novelty seeking behavior. Also, the effect of pre-injection of galantamine, an effective agent in the treatment and prevention of Alzheimer's disease, for reversal of...
متن کاملUse of Colchicine in Cortical Area 1 of the Hippocampus Impairs Transmission of Non-Motivational Information by the Pyramidal Cells
Colchicine, a potent neurotoxin derived from plants, has been recently introduced as a degenerative toxin of small pyramidal cells in the cortical area 1 of the hippocampus (CA1). In this study, the effect of the alkaloid in CA1 on the behaviors in the conditioning task was measured. Injections of colchicine (1,5 μg/rat, intra-CA1) was performed in the male Wistar rats, while the animals were s...
متن کاملThe cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking
Novelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we exam...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmacology
سال: 2013
ISSN: 0253-7613
DOI: 10.4103/0253-7613.111945